A cleric sacred fist build is viable, but will not be high damage as you'll likely prioritize Dex and Wis for AC, neither of which contributes to damage output. Furthermore, using the bracer slot as a weapon means you have 2 equipment slots less than a weapon user.
EDM Str + Cha doubleweapon builds are top tier in firepower, but you definitely do need a PTWF crookweave to play one as the Dex requirement to take the actual feat is crippling otherwise.
Two-handed is generally not really worth it IMO, as the damage gained from Str is eclipsed by feats, buffs and ER3 metal forging. You also lose significant AC by not using a shield. Monkey gripping dual 2 handers is an option, but you need significant AB boosts to offset the loss in accuracy.